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Unique methods to measure intestinal water and cotransporter regulation
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Background

Absorption of monosaccharides in the small intestine is pivotal for caloric intake of mammalians and adjusted in accordance with food supply, food composition, and energy demand in diverse physiological and pathophysiological situations. In respect to caloric intake, D-glucose, D-galactose, and D-fructose are the most relevant monosaccharides. For absorption, monosaccharides must cross a layer of epithelial cells that are connected by tight junctions which do not allow permeation of monosaccharides. Because monosaccharides are hydrophilic, they cannot permeate cell membranes passively. Hence, for absorption of D-glucose, D-galactose, and D-fructose, transporters in the luminal brush border membrane and basolateral membrane of small intestinal epithelial cells are required. 

 

The use of oral rehydration solutions is common practice for treating and preventing dehydration during times of illness and/or sweat loss. Oral rehydration solutions leverage these sugar cotransporters due to other common water transporters being blocked by toxins where water absorption is temporarily suspended. The use of amino acid cotransporters is also of interest in the oral rehydration solution, specifically the SLC family.

What we're looking for

• Consultations/connections with experts • A research collaboration with the desired goal of utilizing validated intestinal models for testing different compositions of oral rehydration solutions and their impact of intestinal water absorption, solute absorption, and potential to regulate cotransporter activity (specifically sugar and amino acid cotransporters)

Solutions of interest include:
  • We are seeking to connect with key opinion leaders in the area
  • Established, unique, or novel methodologies to measure outcomes
  • Novel formulations/bioactives to augment intestinal water absorption
Our must-have requirements are:
  • Model must be capable of assessing intestinal water absorption OR
  • Model must be capable of assessing intestinal solute absorption OR
  • Model must be capable of assessing cotransporter regulation
  • Reason to believe the model can deliver the targeted outcomes mentioned above
Our nice-to-have's are:
  • System / model has the flexibility to be adapted to other health related outcomes such as gut health etc
  • Partner would ideally be able to run and execute the model on behalf of the company for specified health related outcomes
What's out of scope:
  • Animal or animal derived models or systems
Acceptable technology readiness levels (TRL):
Levels 1-9
What we can offer you
Eligible partnership models:
Sponsored research
Benefits:
Sponsored Research
Funding is proposal dependent, but an accepted proposal could expect support in range of $25,000 - $100,000 USD (milestone dependent) with the potential for follow up funding.
Expertise
Partners will interact with a project lead to mutually develop a project plan and engage in regular meetings to ensure success. Partners will have access to company experts as appropriate.
Q&A with the company

The Q&A is now closed.

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Q.
I am thinking of submitting a proposal on: "Unique methods to measure intestinal water and cotransporter regulation" I need to ask if it possible to use remains from cows/sheep as it is not allowed to use animal models.
1
A.
Hello Dr. Borjac, Thank you for your inquiry. It is possible to use some remains like this on occasion. I would encourage you to submit the proposal and we can evaluate with our animal testing team.
Team Member, Reviewer, Private Company
March 19, 2024
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Q.
If there is an applicable system that addresses several but not all of your listed must-haves, are you still interested in receiving the proposal? For example, if it can assess specific cotransporters and solutes but doesn't directly assess water absorption. What we believe the system could be modified to address all three must-haves but currently only addresses some of them?
1
A.
Hello Dr. Novokhodo, Thank you for your message. Yes, if you believe the system could be modified to address all three must-haves then we would love to consider your proposal.
Team Member, Reviewer, Private Company
April 10, 2024
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