Funding Opportunities with Industry

Ventricular heart tissue samples and linked clinical data

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Get them answered by the team at Bayer Pharma.

Background

Bayer’s Pharmaceuticals Research & Development division is working on potential future therapies for patients with cardiovascular diseases.

Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide. By seeking ventricular heart tissue samples and associated clinical data from patients with end-stage heart failure, our R&D division aims to explore the patient-specific pathomechanisms and relevant targets that drive cardiovascular disease progression, uncovering unique insights into the variability of heart failure manifestations.

The integration of actual patient samples with comprehensive clinical data is crucial for the development of tailored therapeutic approaches in a field where current treatment options may not fully address the diverse needs of the patient population.

What we're looking for

We are seeking ventricular heart tissue samples and linked clinical data from patients with end-stage heart failure. We are seeking partnerships with both fee-for-service providers and also academic and public institutions who could provide such material and clinical data.

Our must-have requirements are:

Tissue samples must be accompanied by linked clinical data of those patients (at least diagnosis, medication, imaging data (echocardiogram or cardiac MRI)) – available in an electronic format
Tissue samples must be available already (not collected upon demand)
The allowance by the donors and the license we could take to do research & development with the tissue samples, the clinical data and the results of using both.
You must be able to show us the detailed wording of the patient informed consent, if requested.

Our nice-to-have's are:

Longitudinal clinical data of those patients
Plasma samples of those patients in addition to the tissue samples (with a similar collection period)
If there are follow-up tissue samples available from patients with left ventricular assist devices

What's out of scope:

Tissue samples for which no linked clinical data of those patients is available

Acceptable technology readiness levels (TRL):

Levels 3-9

What we can offer you

Eligible partnership models:

Sponsored Research

We are interested in follow-on research collaborations with relevant teams, including sponsored research or involvement of collaborators on a consultancy basis.

Who we are

Bayer is a German multinational pharmaceutical and life sciences company with a more than 150-year history and core competencies in the areas of health care and agriculture.

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Reviewers

Gorden Redlich

Head of Strategic Outsourcing & Externalization

Alberto Nobili

Senior Director

Q&A with Bayer Pharma

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Is Bayer expecting to obtain the actual tissue samples themselves or would it be acceptable to have them remain with the institution as part of a proposed research collaboration?

Mike Flock, Corporate Relations, University of Pittsburgh

April 3, 2024

Hi Mike, ideally we would like to get those samples into our hands. But this might not be attractive enough for you (just selling the material/data). And I guess, this is why you are asking. At first, we would need to know, if a potential partner has those samples/data. If so, we need to find an agreement, how to interact, which is attractive for both. In principle, this could then also be a research collaboration (whatever it looks like in the end). Best regards, Gorden

Gorden Redlich, Head of Strategic Outsourcing & Externalization, Bayer Pharma

April 3, 2024

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Thanks, Gorden. We do have faculty with relevant biobanks, although want to make sure there is a definitive opportunity for collaborative research before asking them to submit proposal(s) involving such samples/data.

Mike Flock, Corporate Relations, University of Pittsburgh

April 10, 2024

Dear Mike, There is an opportunity for collaborative research. However, first we need to know, if the must-haves are given. Best regards, Gorden

Gorden Redlich, Head of Strategic Outsourcing & Externalization, Bayer Pharma

April 11, 2024

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We have a biobank of human myocardium that may match your needs. The proposal asks "What is your research hypothesis and what is the rationale?" Is the intent for us to propose our own studies?

Kenneth Campbell, Principal Investigator, University of Kentucky

April 4, 2024

Dear Kenneth, primarily the intent is for us to get access to such material and data to do research at Bayer. However, if you have a proposal for whatever kind of joint research, we would also be interested to discuss. Best regards

Gorden Redlich, Head of Strategic Outsourcing & Externalization, Bayer Pharma

April 4, 2024

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Would heart ventricle tissue from autopsy cases be eligible?

Kenzo Washington, Research Associate, Georgetown University

April 17, 2024

Dear Kenzo, in principle yes, if the must-haves are given. Best regards, Gorden

Gorden Redlich, Head of Strategic Outsourcing & Externalization, Bayer Pharma

April 18, 2024

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Is it possible for a non-scientist site user to obtain a PDF of the application template? It would be helpful to see the application contents before discussing the opportunity with faculty.

Caitilin Mohr, Corporate Relations, University of Virginia

May 28, 2024

Dear Caitilin, I would hand over this question to the Halo support team.

Gorden Redlich, Head of Strategic Outsourcing & Externalization, Bayer Pharma

May 29, 2024

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Cardiovascular